Resident Evil Requiem Safe Codes Guide: Every Location and Combination
Five locked safes stand between you and a much easier run through Rhodes Hill and the ARK facility, and cracking every one of them unlocks the "No Safe is Safe" trophy.
Capcom loves hiding vital resources behind dial locks in Resident Evil Requiem. Every Med Injector, Antique Coin, and box of bullets locked away in these safes matters when the game starts punishing you for being underprepared. Leaving one shut is basically asking for trouble later on. If you're still shaky on basic survival before locks even become a concern, our beginners guide will get you sorted.
The catch is the codes aren't fixed. Playing on Insanity mode scrambles every combination, so a code you memorized on Standard is worthless once you bump up the difficulty. Below are the exact dial turns for both settings, along with what each safe actually rewards you.
Every Safe Code, Standard and Insanity
The dials need to be spun in the exact direction listed. Get one turn wrong and you're starting the sequence over while whatever's in the room with you closes the distance.
Down in the ARK Facility
The ARK stops holding back once you arrive, so these two safes matter more than they look.
The Sterilization Chamber safe sits at the rear of the room, but the space is crawling with Lickers. Popping it open mid-fight is a fast way to lose your head, so clear the room first if you can manage it. The code itself is on a piece of paper in the Anteroom, tucked behind a large Umbrella Corporation logo. Crack it and you're walking away with 15 Handgun Bullets, a Med Injector, and a Molotov Cocktail, exactly the kind of stockpile you'll want before the gauntlet that follows.
The Monitor Control Room safe is across from the door you enter through, next to the lobby that needs two orbs to open. The room itself is quiet compared to most of the ARK, so this one's lower risk. Find the code in Bioweapon Repository 05, inside the middle shipping container on the right. Opening it hands you a Med Injector, an Acid Bottle, and an Empty Bottle, ingredients you'll want on hand for crafting ahead of the late-game boss fights.
Once that door swings open, "No Safe is Safe" triggers if you've cleared all five. Our trophy and achievement guide breaks down everything else you'll need for a full completion run.
Back at Rhodes Hill Care Center
You'll spend a good chunk of your early playtime here, and you're underpowered the whole way through, so clearing threats before you start dialing in codes is worth the extra minute.
The Basement Furnace safe takes the most legwork. You need a Joint Plug to reach the forklift room in the basement, then head west of the furnace to a small office. The code, oddly enough, is found during Leon's segment in a warped closet up in the attic. Open it as Grace and you get the Raccoon Roundup Map for Rhodes Hill, which automatically marks every Mr. Raccoon collectible in the zone, plus ten Handgun Bullets. Skip this one and the collectible hunt turns into a slog.
The Examination Room safe is in the back right corner when you enter from the East Wing Lobby. Its code is buried in a pile of broken lockers outside the Conference Room. It's good for three more Antique Coins, and stacked with the Bar safe below, that's enough currency to meaningfully boost your survivability before things get worse.
The Bar and Lounge safe sits behind the bar on a wooden shelf, second floor. The code requires a trip through the Custodian's Office corridor to the second floor office. Three Antique Coins are waiting inside, and Grace's S&S M232 pistol is sitting close by too. Grab both.
One last one worth knowing about so it doesn't waste your time: there's a safe behind the desk in the Waiting Room that's already unlocked, no code needed. On Standard, it's got two free Antique Coins. On Insanity, it's empty, a small, mean joke from the developers, and it won't count toward your achievement either way.
